Tesamorelin

Tesamorelin is a synthetic peptide that acts as a growth hormone-releasing hormone (GHRH) analog. It is primarily used to increase the release of growth hormone (GH) from the pituitary gland, which in turn stimulates the production of insulin-like growth factor-1 (IGF-1). Tesamorelin is FDA-approved for a specific use but is also explored in other areas of research.

Mechanism of Action:
Tesamorelin binds to *GHRH receptors* in the pituitary gland, mimicking the action of natural GHRH.
This stimulates the release of GH, leading to increased IGF-1 production in the liver.
GH and IGF-1 together promote fat metabolism, protein synthesis, and overall tissue regeneration.

Approved Uses:
Treatment of HIV-Associated Lipodystrophy:
   Tesamorelin is FDA-approved for reducing excess abdominal fat in patients with *HIV-associated lipodystrophy*, a condition where fat distribution becomes abnormal due to HIV infection or antiretroviral therapy.